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The Effect of Fsh and Estradiol Benzoate on Hormonal Levels and Growth in Rats Treated with Tamoxifen Citrate | Abstract
Scholars Research Library

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12013805565

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Abstract

The Effect of Fsh and Estradiol Benzoate on Hormonal Levels and Growth in Rats Treated with Tamoxifen Citrate

Author(s): Ali Mojtahedin

Tamoxifen disturbs spermatogenesis and administration of FSH and estradiol benzoate (EB) may improve spermatogenesis. Spermatogenesis and hormonal levels have direct relation. Therefore, this study was conducted to investigate the effect of FSH and EB on hormonal levels and growth in male rats treated with Tamoxifen citrate (TC). Rats were assigned to 4 groups (n=5) including rats treated with TC 1) without hormone therapy, 2) daily dose of 7.5 IU FSH for 10 consecutive days, 3) daily dose of 12.5 µg EB per rat for 10 consecutive days and 4) daily dose of 7.5 IU FSH per rat and 12.5 µg EB per rat for 10 consecutive days. The blood samples were collected to measure of FSH, LH and testosterone. Results showed that oral gavage of TC and hormones had no significant effect on growth performance of rats. Oral gavage of TC significantly decreased the serum concentrations of testosterone, FSH and LH. Administration of FSH and FSH+EB also increased the serum concentrations of testosterone, FSH and LH. However, administration of EB did not improve hormonal levels. It can be suggested the use of FSH for treatment of infertility in men with spermatogenesis deficiency.