Introduction: Changes in plasma lipid profile and hypertension are the risk factors for acquired heart disease that can be controlled to reduce the risk of heart attack and developing heart disease. The fundamental mechanism controlling these factors is the use of drugs such as cholesterol and LDL levels, blood fats and blood pressure lowers. This study aimed to investigate the effect of herbal medicine Lowerchol on the lipid profile, blood pressure and enzymes AST and ALT in dyslipidemia patients with a history of cholesterol-lowering drug, atorvastatin, and individuals who consumed the cholesterol level lowering drugs for first time. Material & Method: In this clinical trial, 100 patients with dyslipidemia and hypertension were selected. Patients were asked to take the capsule containing 888 mg of phytosterols and 500 mg of Cyclanthera pedata fruit extract after their meals, 2 times daily for 2 months. Results: Compare lipid profile and enzyme concentration of people who had a history of atorvastatin showed no significant changes in ALT, AST, and HDL and triglyceride enzyme levels, but after taking Lowerchol, the amount of cholesterol at a rate of %10.04 (P<0.0001) and LDL at a rate of %14.37 (P≤0.0008) increased. In contrast, in people who had no lipid-lowering drug history showed a significant decrease of enzymes ALT and AST, and decrease in cholesterol level was %10.66 (P≤0.0018) and in triglyceride was%17.49 (P=0.0014). However, it was not seen any significant changes in LDL and HDL enzyme levels. All the patients undergoing treatment of Lowerchol showed decrease in their blood pressure as much as 2 to 3 unit and its stability. According to the mentioned results, it is not suggested replacement of Lowerchol for common cholesterol endogenous lowering drugs. The drug should be taken as a supplement of lowering cholesterol synthesis drugs or be prescribed as a medicine of lowering blood pressure.