One of considered factor in diabetes disease is increase on insulin level, which is the most important mechanism of insulin adjustment measure through HSL (hormone sensitive lipase). There are conflicting studies about the effect of exercise training on HSL. Therefore, the aim of this investigation is to was to investigate the effect of 8 weeks of resistance exercise training on HSL levels and lipid profile levels in patient with type 2 diabetes. Twenty four adult women with type 2 diabetes were divided randomly into 2 groups: Training (n=12) and control (n=12). The subjects of training group practiced in 8 weeks resistance trainings, 3 sessions a week, with intensity 50 – 80 % 1RM. HSL levels and some metabolic parameters such as lipid profiles, glucose, insulin and HOMA-IR were measured by ELISA method before and after intervention. ANCOVA test was used to analyse between-group data and paired ttest for analyzing inter-group data. After 8 weeks resistance training, LDL, insulin and HOMA-IR levels significantly decreased in training group as compared to control group (respectively P= 0/04, P= 0/002, P= 0/006) While HSL, cholesterol, TG and HDL-C levels didn’t significantly change. The results of this research indicates that after one period of resistance exercise trainings, HSL levels didn’t significantly change while LDL levels, insulin and HOMA-IR significantly change. Therefore resistance training can be used as an effective factor to improve insulin sensitivety in type 2 diabetes patients.