The aim of this review outlines the application of mathematical models for study of release phenomenon of drug from dosage forms. Mathematically it is easy to identify the designing of a dosage form and it can be used to predict the effect of device design parameters on the release kinetics of the formulation. It is easier to obtain the quantitative analysis of data for dissolution release rate by using these models. The choice of selection of best model depends on the desired ability and accuracy of the model. The mathematical modeling can finally to optimize the design of a therapeutic system with programmed release rate characteristics which is now prerequisite for drug delivery system. This review gives the idea about the various mathematical modeling and their applications in drug delivery systems.