The present research was aimed to explain the role of metacognition and dimensions of Perfectionism in prediction of the consequences of individuals with obsessive-compulsive disorder. The research was descriptive-correlational. The population consisted of all the patients with obsessive-compulsive disorder who attended active clinics in Tehran city in order to receive mental health and medication services. In this regard, 80 individuals were chosen from the mentioned sample size using convenience sampling method and were assessed though standard questionnaires. The obtained data were analyzed using multivariate regression method and Pearson Correlation Coefficient. The findings demonstrated that metacognition, positive perfectionism and negative perfectionism have significance correlation with psychological consequences. Moreover, the results of the regression analysis indicated that 56 percent of variance related to psychological consequences is explained by metacognition, positive perfectionism and negative perfectionism. Increase in the level of metacognition and negative perfectionism leads to increase in the level of psychological consequences and increase in the level of positive perfectionism leads to decrease of psychological consequences.