In order to evaluate the effects of the toxicity of EGME, an experimental study has been carried in laboratory of animal echophysiology on 30 male rabbits (Oryctolagus Cuniculus). These latter was treated with EGME introduced by cutaneous way (intradermal injection) with two increasing doses 200 and 300 ppm for 4 successive weeks. The chemical treatment with the EGME causes a variation in the hematological and biochemical parameters: the significant disturbance in the cellular parameters of blood which include the numeration of blood cells (white blood celles, red blood cells, hemoglobin, hematocrit , the mean corpuscular volume and mean corpuscular hemoglobin) in individuals treated by the EGME compared to the witnesses ,an increase in the weight of liver was observed especially in rabbits treated by important doses. In addition, the serum concentration in glucose was significantly dcecreased compared with the witness to all treated rabbits. A significant increase in the rate of cholesterol, triglycerides and total protein was detected in rabbits treated by report to the witnesses. Finally, the obtained results highlight a reduction of the rate of glutathione GHS in studying organs such as the liver, testes and epididymis. According to our results we can conclude that the exposure to the EGME causes important biological variations.