Chronic atopic dermatitis (AD) is a distressing pruritic condition that has become increasing prevalent. Despite extensive research, children and adults still suffer from this devastating disease. The exact pathogenesis; interplay between the skin barrier innate defects, epidermal dysbiosis, immune aberrancy and relentless itch-scratch viscous cycle in chronic AD is still unresolved. Cognitive co-morbidities and the phenomena of allokinesis are not fully scientifically explained. Notable achievements were made in the domain of immune cascades dysfunction; with the advent and discovery of biologics. The complex nature of AD is still an interesting research area for pharmacologists, neurologists, cognitive scientists, microbiologists, gastroenterologists and dermatologists.