Two simple, accurate, precise, economical and reproducible UV spectrophotometric methods have been developed for simultaneous estimation of Telmisartan (TEL), Hydrochlorthiazide (HTZ) and Amlodipine besylate (AML) in pure bulk drug and tablet dosage form. The stock solutions were prepared in methanol followed by further required dilutions with distilled water. Method I is based on first order derivative spectrophotometry and absorbances were measured at 252 nm, 271 nm and 239 nm, being the zero-crossing points for telmisartan, hydrochlorthiazide and amlodipine respectively. Method II is based on the muticomponent analysis. The absorbance maxima of telmisartan, hydrochlorthiazide and amlodipine was found to be at 296 nm, 272nm and 238nm respectively. All the three drugs obey Beer’s law in the concentration range of 5-30μg/ml. The results of analysis for both methods were tested and validated for various parameters according to ICH guidelines. The utility of the developed methods has been demonstrated by analysis of commercially available dosage form.
