Scholars Research Library

Scholars Research Library

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Der Pharmacia Lettre


Validated UV spectrophotometric method for quantitative determination of candesartan cilexetil in bulk and pharmaceutical dosage form

Author(s): Panchumarthy Ravisankar, V. Sree Vidya, K. Manjusha, Y. Naga Mounika and P. Srinivasa Babu

In the present work simple, precise, specific, accurate and cost effective UV spectrophotometric method has been developed for the estimation of Candesartan Cilexetil in pharmaceutical formulation. The wavelength of the Candesartan Cilexetil detection was 258 nm in methanol and obeys Beer’s law in the concentration range of 10 - 50 μg /mL with a correlation coefficient of 0.9999. The results of analysis were validated by recovery studies. The percentage recovery of the drug after standard addition was found to be 99.45 - 99.85 %. The relative standard deviation was found to be < 2.0 % in all cases. The result of analysis was found to be 99.83±0.226 %. The Proposed spectrophotometric method was validated as per the ICH Q2 (R1) guidelines. The proposed method was found to be suitable for the quantitative determination of Candesartan Cilexetil in bulk form and pharmaceutical formulations.