There has been an increasing interest in the chemistry of pyridazinone derivatives because of their biological significance. Pyridazinones have been reported to possess variety of biological activities like antidiabetic, anticancer, anti-AIDS, cardiovascular, antiinflammatory, anticonvulsant and cerebroprotective, analgesics, antidepressant, anticonvulsant, antiasthmatic, anti-HIV1, antimicrobial, insecticidal etc. Various compounds such as Levosimendan, Amipizone, Indolidan, Imazodan and Pimobedan are few examples of pyridazinones that are active as cardiotonic agents. The synthesis of novel pyridazinone derivatives and investigation of their chemical and biological activities have gained more importance. The biological profile of new generations of pyridazinones presents much progress with regards to the old compounds
