Type 1diabetes is a disease that typically occurs in childhood and adolescence and it is caused by the destruction of beta cells in the islets of pancreas resulting in insulin deficiency. Finally, it leads to high glucose levels in the blood. Insulin therapy is easier to maintain the desire blood sugar levels but it has multiple problems. Xenotransplantation has crossed the boundaries of transplanting organs and tissues to another species. Islet transplantation offers an attractive alternative treatment for type 1 diabetes. In this method host beta cells that have been destroyed are replaced by new beta cells in the islets. Transplanted beta cells are able to change in blood glucose levels. Pig is the most likely source of animal organs and cells for transplantation into humans. But this method has not abolished all complications. Hosts are facing mainly two problems one is refusal of the organ and cells, and another is the possibility of launching novel infections into the hosts. For successful implication of this method above problems must be overcome.