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A murine model study on the effect of Garcinia kola on body weight | Abstract
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Abstract

A murine model study on the effect of Garcinia kola on body weight

Author(s): Osifo UC, Akpamu U, Otamere HO. Ekhator CN

The effects of Garcinia kola seed on body weight was studied on adult male rabbits of comparable weight. They were divided into three experimental groups (X, Y, Z) and a control group (A), each consisting of six animals. For six weeks, group X, Y and Z received in addition to normal feed and water 1200mg/kg, 1500mg/kg and 1800mg/kg per body weight respectively of the reconstituted powdered Garcinia kola. Prior to the administration of Garcinia kola and at the end of each week, weights were measured and the mean recorded at the end of the experiment. Comparable weights were observed before and after acclimatization. However, at the end of the six weeks study, there was a dose dependent fall in body weight in the experimental groups and was statistically significant (p<0.05) for group Y (1.47±0.08 kg) and Z (1.48±0.06 kg) compared to the control (1.55±0.06 kg). The observed outcome of this study suggests Garcinia kola seed has potentials for weight management in overweight and thus antiobesity.