An estimated 500,000 women die from potentially preventable causes of pregnancy and childbirth each year with up to an estimated quarter of these deaths occurring as a consequence of haemorrhage. The Midwives being the first point of contact play a central role in addressing this global issue. This study was designed to assess the knowledge of strategies used in the prevention and management of postpartum haemorrhage (PPH) by midwives in Bayelsa State Nigeria. A purposive non-probability sampling technique was used to select a sample frame of eighty midwives working in two government hospital, in Bayelsa State Nigeria. Data were collected using a self-developed questionnaire. Descriptive and inferential statistics were used to analyze the data generated with 5% level of significance. The study revealed that majority of the study population (85%) had high level knowledge of strategies used in the prevention and control of PPH and strategies used by early cord clamping, bladder emptying, placing the woman in a trendeleburg position, uterine massage after delivery of the placenta and the use of uterotonics with oxytocin being the most commonly used. Majority of respondents (73.8%) have heard of anti-shock garment but only(52.5%) used it in the management of PPH. There was no significant association between the professional qualification (P-Value=0.349), rank (P-Value=0 .088) of midwives and their level of knowledge of strategies used in the prevention and management of PPH with p>0.05. It is recommended that refresher courses where nurse-midwives and other health care professionals will be trained and retrained on the strategies used in the prevention and management of PPH should be periodically with Emphasis on the use of anti-shock garment.