Diabetes Mellitus (DM) is a heterogeneous metabolic disorders characterized by common feature of chronic hyperglycemia with disturbance of carbohydrate, fat and protein metabolism The incidence of diabetes mellitus is increasing day by day all over the world. DM is a leading cause of morbidity and mortality the world over. It is estimated that approximately 1% of population suffers from DM. This study is intended to access the various predisposing factor in type 2 diabetes mellitus in patients in South Malabar region. To the best of our knowledge this type of study was not conducted earlier. It can be therefore be interpreted that in the South Malabar region of Kerala the prevalence of diabetes can be mainly attributed to the food habits, reduced physical activity and family history. Sex and age also are relevant factors as they cover more than 50% of their significance. It is observed that male subjects are more susceptible for type 2 diabetes mellitus. Older people are at a greater risk of being diabetic. Primary standard of education and rural residence had shown clear association with incidence of diabetes. Patient awareness has a greater role in preventing the progression of the disease. Education therefore is a very important factor Dietary habits and body built of the patients are also significant factors in the leading to the development of diabetes. Dietary restrictions must be insisted for diabetic subjects and people must be informed of the importance of taking food rich in dietary fibers and antioxidants. This is because that people from the rural region mainly consumes carbohydrate and fat rich food due to its wide availability.