Manufactured science is a prominent interdisciplinary consolidating designing with science. As a double reason discipline, SynBio is carrying enormous changes to many fields and giving incredible advantages to people. Be that as it may, because of its trait of intricacy and vulnerability, SynBio additionally presents likely biosafety and biosecurity chances. Biosecurity gambles allude to unapproved access, misfortune, burglary, abuse, redirection or purposeful delivery. On the off chance that a biosecurity mishap occurs, it would represent a gigantic danger to people and nature. In this manner, it is critical to lay out a bunch of guidelines and the board rehearses for the biosecurity dangers of SynBio. In this paper, we summed up the wellsprings of the biosecurity dangers of SynBio, from its exploration materials, items, advances, data to DIY engineered science. We surveyed and broke down the ongoing circumstance of guideline and the executives of biosecurity for SynBio in the global local area and in China. We found that in many nations and locales, SynBio gambles generally follow the guideline and the executives of Hereditarily Adjusted Organic entities which has escape clauses whenever applied to the guideline for SynBio with next to no changes. Here, we proposed ideas for the Chinese-highlighted guideline and the board of biosecurity for SynBio, including a start to finish overseeing structure, a research organization execution instrument, an Engineered Science Lab Biosecurity Manual defending framework, and reinforcing biosecurity schooling on manufactured science and self-guideline mindfulness among pertinent staff. Through this work, we expect to work on the normalized course of biosecurity guideline and the executives for SynBio in China and subsequently map out a serene, productive, and reasonable improvement way for manufactured science.