Vitiligo also known as Leukoderma is caused by the loss of pigment, resulting in irregular pale patches of skin. Vitiligo develops patches of de-pigmented skin appearing on extremities. A team of scientists at King’s College London have discovered that Piperine and its synthetic derivatives can stimulate pigmentation in the skin. The present study evaluates the pharmacological response of repigmentation to a herbal topical formulation incorporated with piperine with and without UV radiation using New Zealand strain rabbits. Although the group deprived of UV radiation took more time for repigmentation, the pattern was more homogenous.