In this review we present general paths and implementations for the Schiff bases preparation. And we highlight the most important examples of Schiff bases derived from components belonging to this type, that show efficacies of bacterial, anti-malarial, virus and fungi that have been announced in the literature. The relationship between Schiff bases and other pharmacological activities, such as antiproliferative activities, are not included in this review. Schiff bases are versatile ligands that are prepared from the condensation of moieties of carbonyl with primary amines. These components are very substantial in fields of pharmaceutical and medicinal because of their wide spectrum of biological activities. Most of them show biological activities like antitumor also antifungal, antibacterial efficacy. Metal complexes derived from the Schiff base ligands with efficiency of biological have been extensively studied. This review epitomizes the preparation and biological efficiencies of Schiff bases and its complexes. Azomethine association with Schiff base plays a substantial role in the range of medical with several efficiencies of pharmacological like efficiency of anticancer, antiviral, tuberculosis, and antimicrobial activity. The efficacy of these pharmaceutically beneficial drugs in treating microbial infections and other activities has encouraged the expansion of some of the more powerful and important mineral compounds and compounds. Schiff's bases and complexes are remarkably effective compounds, and extensive biochemical and medical studies have confirmed that these molecules are effective against different strains of microorganisms. This review was summarized to know the chemistry of different derivatives of substituted Schiff bases and there are complexes with different minerals along with their antimicrobial activities. The potency of these pharmaceutically useful drugs in treatment of microbial infections and other activities encouraged the expansion of some more potent and significant compounds and metal complexes. Schiff bases and there metal complexes are remarkably effective compounds, extensive biochemical and medicinal studies have confirmed that these molecules are effective against various strains of microorganisms. This review is summarized to know about the chemistry of different derivatives of substituted Schiff bases and there metal complexes with various metals along with their anti-microbial activities.