Scholars Research Library

Scholars Research Library

A-Z Journals

+44 7389645282

Carol William

Managing Editor, Journal of Natural Product and Plant Resources, UK


  • Editorial   
    Mechanism For METTL6-mediated M3C RNA Methylation In Terms Of Its Structure.
    Author(s): Carol William*

    RNA modifications are critical in mediating how RNAs perform biological functions. Despite being less common, 3-methylcytidine (m3C) is discovered to be widely present in tRNAs, rRNAs, and mRNAs. A m3C methyltransferases for tRNAs, including transfer, is human METTL6 (UGA). In the presence of S-adenosyl-L-methionine, we were able to solve the structure of human METTL6, and an enzyme assay revealed that recombinant human METTL6 is active towards transfer (UGA). A putative tRNA binding area on the surface of METTL6 was identified by structural analysis, which also revealed the specific interactions between S-adenosyl-L-methionine and METTL6. In the near future, the design of effective METTL6 inhibitors will undoubtedly become clearer as a result of structural study that is accompanied by biochemical enzyme testing.. Read More»

    Abstract PDF

Awards & Nominations

Google Scholar citation report
Citations : 5585

Journal of Natural Product and Plant Resources received 5585 citations as per Google Scholar report

5+ Million Readerbase

Indexed In