Research Article
Formulation Optimization and In-Vivo Evaluation of Orodispersible Tablets of Almotriptan for the Effective Treatment of Migraine
Author(s): Sirisha Y*, Gopala Krishna Murthy TE and Srinivasa Rao A
The present research work focuses on formulation, optimization and in-vivo evaluation of the orodispersible tablets of Almotriptan to achieve the desired bioavailability and give a rapid relief from the migraine headache.
Methods: The optimization was done using 22 factorial design and the formulation were subjected to several in-vitro evaluation studies. Along with stability studies for 6 months. The optimised stable formulation of Almotriptan was subjected to in-vivo studies employing animal models (rabbits) to determine the plasma concentration of the drug within required time after oral administration and the pharmacokinetic parameters such as Cmax, Tmax, AUC and others were calculated. In-vitro-in-vivo correlation was done by deconvolution using Wagner-Nelson method and the graphs were plotted to report the correlation of drug.. Read More»
